Publications

T.-M. Fu, G. Liu, D. E. Milkie, X. Ruan, F. Gorlitz, Y. Shi, V. Ferro, N. S. Divekar, W. Wang, H. M. York, V. Kilic, M. Mueller, Y. Liang, T. A. Daugird, M. J. Gacha-Garay, K. A. Larkin, R. C. Adikes, N. Harrison, C. Shirazinejad, S. Williams, J. L. Nourse, S.-H. Sheu, L. Gao, T. Li, C. Mondal, K. Achour, W. Hercule, D. Stabley, K. Emmerich, P. Dong, D. Drubin, Z. J. Liu, D. Clapham, J. S. Mumm, M. Koyama, A. Killilea, J. Javier Bravo-Cordero, C. D. Keene, L. Luo, T. Kirchhausen, M. M. Pathak, S. Arumugam, J. K. Nunez, R. Gao, D. Q. Matus, B. L. Martin, I. A. Swinburne, E. Betzig, W. R. Legant, S. Upadhyayula, "A multimodal adaptive optical microscope for in vivo imaging from molecules to organisms", bioRxiv, 2025.06.02.657494.

J. Wang, G. Qiao, H. Tan, M. J. Li, K. Wang, J. Xu, M. Janowski, T.-M. Fu, P. Walczak, Y. Liang, "Intravital multimodal imaging of human cortical organoids for chronic stroke treatment in mice", bioRxiv, 2025.0705.663297.  

M. J. Li, J. Wang, M. Walczak, Y. Qiu, C. Russell, M. Janowski, P. Walczak, Y. Liang, T.-M. Fu, "Tunable Bessel beam two-photon fluorescence microscopy for high-speed volumetric imaging of brain dynamics", eLife, 15:RP110228 (2026).

F. Liu, T.-M. Fu, "Material and design strategies for chronically-implantable neural probes", NPG Asia Materials, 17, 32 (2025).  

X. Ruan, M. Mueller, G. Liu, F. Görlitz, T.-M. Fu, D. E. Milkie, J. Lillvis, A. Kuhn, J. C. Chong, C. Y. A. Herr, W. Hercule, M. Nienhaus, A. N. Killilea, E. Betzig, S. Upadhyayula, "Image processing tools for petabyte-scale light sheet microscopy data", Nature Methods, 21, 2342-2352 (2024).  

M. de Jesus, A. H. Settle, D. Vorselen, T. K. Gaetjens, M. Galiano, Y. Romin, E. Lee, Y. Y. Wong, T.-M. Fu, E. Santosa, B. Y. Winer, F. Tamzalit, M. S. Wang, A. Santella, Z. Bao, J. C. Sun, P. Shah, J. A. Theriot, S. M. Abel, M. Huse, “Single-cell topographical profiling of the immune synapse reveals a biomechanical signature of cytotoxicity”, Science Immunology, 9, eadj2898 (2024).

K.K.L. Wong, T. Li, T.-M. Fu, G. Liu, C. Lyu, S. Kohani, Q. Xie, D.J. Luginbuhl, S. Upadhyayula, E. Betzig, L. Luo, “Origin of wiring specificity in an olfactory map: dendrite targeting of projection neurons”, eLife, 12:e85521 (2023).

K.B. Emmerich, D.T. White, S.P. Kambhamptati, G.L. Casado, T.-M. Fu, Z. Chunawala, A. Sahoo, S. Nimmagadda, N. Krishnan, M.T. Saxena, S.L. Walker, E. Betzig, R.M. Kannan, J.S. Mumm, “Nanoparticle-based targeting of microglia improves the neural regeneration enhancing effects of immunosuppression in the zebrafish retina”, Communications Biology, 6, 534 (2023).  

A.S. Abdelfattah, J. Zheng, A. Singh, Y.-C. Huang, D. Reep, G. Tsegaye, A. Tsang, B.J. Arthur, M. Rehorova, C.V.L. Olson, Y. Shuai, L. Zhang, T.-M. Fu, D.E. Milkie, M.V. Moya, T.D. Weber, A.L. Lemire, C.A. Baker, N. Falco, Q. Zheng, J.B. Grimm, M.C. Yip, D. Walpita, M. Chase, L. Campagnola, G.J. Murphy, A.M. Wong, C.R. Forest, J. Mertz, M.N. Economo, G.Turner, M. Koyama, B.-J. Lin, E. Betzig, O. Novak, L.D. Lavis, K. Svoboda, W. Korff, T.-W. Chen, E.R. Schreiter, J.P. Hasseman, I. Kolb, “Sensitivity optimization of a rhodopsin-based fluorescent voltage indicator”, Neuron, 111,1547 (2023).

C. Mondal, M.J. Gacha-Garay, K. Larkin, R. Adikes, J.S. Di Martino, C.-C. Chien, M. Fraser, I. Eni-aganga, E. Agullo-Pascual, U. Ozbek, A. Naba, A. Gaitas, T.-M. Fu, S. Upadhyayula, E. Betzig, D. Matus, B.L. Martin, J. Javier Bravo-Cordero, “A proliferative to invasive switch is mediated by srGAP1 downregulation through the activation of TGFβ2 signaling”, Cell Reports, 40, 111358 (2022). 

T. Li, T.-M. Fu, K.K.L. Wong, H. Li, Q. Xie, D.J. Luginbuhl, M.J. Wagner, E. Betzig, L. Luo, “Cellular bases of olfactory circuit assembly revealed by systematic time-lapse imaging”, Cell, 184, 5107-5121 (2021). 

X. Yang, T. Zhou, T.J. Zwang, G. Hong, Y. Zhao, R.D. Viveros, T.-M. Fu, T. Gao, C.M. Lieber, “Bioinspired neuron-like electronics”, Nature Materials, 18, 510-517 (2019). 

R.D. Viveros, T. Zhou, G. Hong, T.-M. Fu, H.-Y.G. Lin, C.M. Lieber, “Advanced one- and two-dimensional mesh designs for injectable electronics”, Nano Letters, 19, 4180-4187 (2019).  

G. Hong, T.-M. Fu, M. Qiao, R.D. Viveros, X. Yang, T. Zhou, J.M. Lee, H.-G. Park, J.R. Sanes, C.M. Lieber, “A method for single-neuron chronic recording from the retina in awake mice”, Science, 360, 1447-1451 (2018). 

T.G. Schuhmann, T. Zhou, G. Hong, J.M. Lee, T.-M. Fu, H.-G. Park, C.M. Lieber, “Syringe-injectable mesh electronics for stable chronic rodent electrophysiology”, Journal of Visualized Experiments, 137, E58003 (2018).                             

T.-M. Fu, G. Hong, R.D. Viveros, T. Zhou, C.M. Lieber, “Highly scalable multichannel mesh electronics for stable chronic brain electrophysiology”, Proceedings of the National Academy of Sciences, 114, E10046-E1005 (2017). 

T. Zhou, G. Hong, T.-M. Fu, X. Yang, T.G. Schuhmann, R.D. Viveros, C.M. Lieber, “Syringe-injectable mesh electronics integrate seamlessly with minimal chronic immune response in the brain”, Proceedings of the National Academy of Sciences, 114, 5894-5899 (2017). 

T.-M. Fu, G. Hong, T. Zhou, T.G. Schuhmann, R.D. Viveros, C.M. Lieber, “Stable long-term chronic brain mapping at the single neuron level”, Nature Methods, 13, 875-882 (2016). 

J. Liu, T.-M. Fu, Z. Cheng, G. Hong, T. Zhou, L. Jin, M. Duvvuri, Z. Jiang, P. Kruskal, C. Xie, Z. Suo, Y. Fang, C.M. Lieber, “Syringe-injectable electronics”, Nature Nanotechnology, 10, 629-636 (2015). 

C. Xie, J. Liu, T.-M. Fu, X. Dai, W. Zhou, C.M. Lieber, “Three-dimensional macroporous nanoelectronic networks as minimally invasive brain probes”, Nature Materials, 14, 1286-1292 (2015). 

G. Hong, T.-M. Fu, T. Zhou, T.G. Schuhmann, J. Huang, C.M. Lieber, “Syringe injectable electronics: precise targeted delivery with quantitative input/output connectivity”, Nano Letters, 15, 6979-6984 (2015).                            

N. Gao, W. Zhou, X. Jiang, G. Hong, T.-M. Fu, C.M. Lieber, “General strategy for biodetection in high ionic strength solutions using transistor-based nanoelectronic sensors”, Nano Letters, 15, 2143-2148 (2015).                                                                      

T.-M. Fu, X. Duan, Z. Jiang, X. Dai, P. Xie, Z. Cheng, C.M. Lieber, “Sub-10-nm intracellular bioelectronic probes from nanowire-nanotube heterostructures”, Proceedings of the National Academy of Sciences, 111, 1259-1264 (2014).            

W. Zhou, X. Dai, T.-M. Fu, C. Xie, J. Liu, C.M. Lieber, “Long-term stability of nanowire nanoelectronics in physiological environments”, Nano Letters, 14, 1614-1619 (2014).                                                                   

X. Duan, T.-M. Fu, J. Liu, C.M. Lieber, “Nanoelectronics-biology frontier: from nanoscopic probes for action potential recording in live cells to three-dimensional cyborg tissues”, Nano Today, 8, 351-373 (2013).                                            

T.-M. Fu, Y. Gao, Y.-Q. Lou, “Starless cloud core L1517B in envelope expansion with core collapse”, The Astrophysical Journal, 741, 113-128 (2011).